Oxyferriscorbone elevates the total iron content of blood but not brain
Identifieur interne : 006443 ( Main/Exploration ); précédent : 006442; suivant : 006444Oxyferriscorbone elevates the total iron content of blood but not brain
Auteurs : D. T. Dexter [Royaume-Uni] ; Jenner [Royaume-Uni] ; Marsden [Royaume-Uni]Source :
- Movement Disorders [ 0885-3185 ] ; 1989.
English descriptors
- KwdEn :
- 2,3-Diketogulonic Acid (pharmacology), Alloxan (pharmacology), Animals, Blood-Brain Barrier (drug effects), Brain (drug effects), Brain (metabolism), Copper (blood), Drug Combinations (pharmacology), Ferric Compounds (pharmacology), Infusions, Intravenous, Iron (blood), Male, Oxyferriscorbone, Parkinson's disease, Rats, Rats, Inbred Strains, Sugar Acids (pharmacology), Total iron content, Zinc (blood).
- MESH :
- chemical , blood : Copper, Iron, Zinc.
- chemical , pharmacology : 2,3-Diketogulonic Acid, Alloxan, Drug Combinations, Ferric Compounds, Sugar Acids.
- drug effects : Blood-Brain Barrier, Brain.
- metabolism : Brain.
- Animals, Infusions, Intravenous, Male, Rats, Rats, Inbred Strains.
Abstract
Following the intravenous infusion of oxyferriscorbone into the tail vein of the rat, the blood and brain metal ion content was measured over the following 72 h period. Administration of oxyferriscorbone increased the total iron content of blood for up to 24 h following intravenous infusion. In contrast, there was no increase in the total iron content of the cerebellum or striatum. Overall, there was no change in total zinc or copper content of the blood or brain following oxyferriscorbone administration. The effect of oxyferriscorbone in Parkinson's disease may not be related to any alteration in total iron content of the brain.
Url:
DOI: 10.1002/mds.870040209
Affiliations:
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Dexter</name></author><author><name sortKey="Jenner" sort="Jenner" uniqKey="Jenner" last="Jenner">Jenner</name></author><author><name sortKey="Marsden" sort="Marsden" uniqKey="Marsden" last="Marsden">Marsden</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:308558973286D1358DB69A95117DBC67EB05977E</idno><date when="1989" year="1989">1989</date><idno type="doi">10.1002/mds.870040209</idno><idno type="url">https://api.istex.fr/document/308558973286D1358DB69A95117DBC67EB05977E/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">003198</idno><idno type="wicri:Area/Istex/Curation">003198</idno><idno type="wicri:Area/Istex/Checkpoint">004473</idno><idno type="wicri:doubleKey">0885-3185:1989:Dexter D:oxyferriscorbone:elevates:the</idno><idno type="wicri:source">PubMed</idno><idno type="RBID">pubmed:2733708</idno><idno type="wicri:Area/PubMed/Corpus">004F74</idno><idno type="wicri:Area/PubMed/Curation">004F74</idno><idno type="wicri:Area/PubMed/Checkpoint">004F74</idno><idno type="wicri:Area/Ncbi/Merge">004534</idno><idno type="wicri:Area/Ncbi/Curation">004534</idno><idno type="wicri:Area/Ncbi/Checkpoint">004534</idno><idno type="wicri:doubleKey">0885-3185:1989:Dexter D:oxyferriscorbone:elevates:the</idno><idno type="wicri:Area/Main/Merge">009796</idno><idno type="wicri:Area/Main/Curation">006443</idno><idno type="wicri:Area/Main/Exploration">006443</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Oxyferriscorbone elevates the total iron content of blood but not brain</title><author><name sortKey="Dexter, D T" sort="Dexter, D T" uniqKey="Dexter D" first="D. T." last="Dexter">D. T. Dexter</name><affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>MRC Movement Disorders Research Group, University Department of Neurology and Parkinson's Disease Society Research Centre, Institute of Psychiatry and King's College Hospital Medical School, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Jenner" sort="Jenner" uniqKey="Jenner" last="Jenner">Jenner</name><affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>MRC Movement Disorders Research Group, University Department of Neurology and Parkinson's Disease Society Research Centre, Institute of Psychiatry and King's College Hospital Medical School, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Marsden" sort="Marsden" uniqKey="Marsden" last="Marsden">Marsden</name><affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>MRC Movement Disorders Research Group, University Department of Neurology and Parkinson's Disease Society Research Centre, Institute of Psychiatry and King's College Hospital Medical School, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation><affiliation wicri:level="3"><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName><wicri:orgArea>Current Address: University Department of Clinical Neurology, Institute of Neurology, National Hospital</wicri:orgArea></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="1989">1989</date><biblScope unit="vol">4</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="176">176</biblScope><biblScope unit="page" to="182">182</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">308558973286D1358DB69A95117DBC67EB05977E</idno><idno type="DOI">10.1002/mds.870040209</idno><idno type="ArticleID">MDS870040209</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>2,3-Diketogulonic Acid (pharmacology)</term><term>Alloxan (pharmacology)</term><term>Animals</term><term>Blood-Brain Barrier (drug effects)</term><term>Brain (drug effects)</term><term>Brain (metabolism)</term><term>Copper (blood)</term><term>Drug Combinations (pharmacology)</term><term>Ferric Compounds (pharmacology)</term><term>Infusions, Intravenous</term><term>Iron (blood)</term><term>Male</term><term>Oxyferriscorbone</term><term>Parkinson's disease</term><term>Rats</term><term>Rats, Inbred Strains</term><term>Sugar Acids (pharmacology)</term><term>Total iron content</term><term>Zinc (blood)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Copper</term><term>Iron</term><term>Zinc</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>2,3-Diketogulonic Acid</term><term>Alloxan</term><term>Drug Combinations</term><term>Ferric Compounds</term><term>Sugar Acids</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Blood-Brain Barrier</term><term>Brain</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Brain</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Infusions, Intravenous</term><term>Male</term><term>Rats</term><term>Rats, Inbred Strains</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Following the intravenous infusion of oxyferriscorbone into the tail vein of the rat, the blood and brain metal ion content was measured over the following 72 h period. Administration of oxyferriscorbone increased the total iron content of blood for up to 24 h following intravenous infusion. In contrast, there was no increase in the total iron content of the cerebellum or striatum. Overall, there was no change in total zinc or copper content of the blood or brain following oxyferriscorbone administration. The effect of oxyferriscorbone in Parkinson's disease may not be related to any alteration in total iron content of the brain.</div></front></TEI><affiliations><list><country><li>Royaume-Uni</li></country><region><li>Angleterre</li><li>Grand Londres</li></region><settlement><li>Londres</li></settlement></list><tree><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Dexter, D T" sort="Dexter, D T" uniqKey="Dexter D" first="D. T." last="Dexter">D. T. Dexter</name></region><name sortKey="Jenner" sort="Jenner" uniqKey="Jenner" last="Jenner">Jenner</name><name sortKey="Marsden" sort="Marsden" uniqKey="Marsden" last="Marsden">Marsden</name><name sortKey="Marsden" sort="Marsden" uniqKey="Marsden" last="Marsden">Marsden</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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